کنفرانس بین المللی میکروالکترونیک ایران

صفحه اصلی / هفتمین کنفرانس بین المللی میکروالکترونیک ایران

Numerical Assessment of Serpentine Microchip Capillary Electrophoresis Channels Over Straight Channels

نویسندگان :

Ehsan Nikkhah¹ Hadi Veladi² Abolghasem Jouyban³

1- دانشگاه تبریز 2- دانشگاه تبریز 3- دانشگاه علوم پزشکی تبریز

کلمات کلیدی :

Microchip capillary electrophoresis،serpentine channel،ibuprofen،phosphate buffer،COMSOL multiphysics

چکیده :

Microchip capillary electrophoresis (MCE) has become a powerful technique for rapid pharmaceutical and biochemical separations. However, the effective separation length in straight microchannels is inherently limited, restricting resolution and analytical performance. To address this challenge, serpentine channel geometries have been proposed to extend the effective length without enlarging the device footprint. In this study, we numerically investigated the advantages of serpentine MCE channels over straight channels using COMSOL Multiphysics. Ibuprofen was selected as the model analyte in a phosphate buffer under an applied potential of 1500 V. Key performance indicators including effective channel length, electric field distribution, migration time, peak broadening, and theoretical plate number were extracted from simulations. The results demonstrated that the serpentine channel increased the effective length from 45 mm to approximately 65 mm, leading to a more uniform electric field distribution and enhanced separation efficiency. Although the migration time in serpentine channels was slightly longer due to the extended path, the narrower peak width resulted in a higher number of theoretical plates compared to the straight channel. These findings confirm the potential of serpentine geometries to improve resolution in pharmaceutical microchip electrophoresis and highlight their suitability for integration into compact lab-on-a-chip platforms.