کنفرانس بین المللی میکروالکترونیک ایران

صفحه اصلی / ششمین کنفرانس بین المللی میکروالکترونیک ایران

Design and Numerical Assessment of a Novel Dielectrophoretic Microfluidic Chip to Separate CTCs

نویسندگان :

Fatemeh Ghaffari¹ Hadi Veladi²

1- دانشگاه تبریز 2- دانشگاه تبریز

کلمات کلیدی :

microfluidics،dielectrophoresis،circulating tumor cells،cell separation،Lab-on-Chip

چکیده :

This paper presents a novel approach to the design of dielectrophoretic (DEP) microfluidic chips optimized for the efficient separation of circulating tumor cells (CTCs). Using advanced simulation techniques, we explore the interaction between electric fields and fluid dynamics to develop a microfluidic device that enhances the selectivity and sensitivity of CTC separation. By employing a simulation-driven design methodology, we systematically optimize key parameters such as electrode geometry, channel dimensions, and flow rates to achieve a high separation efficiency. Our results demonstrate that the proposed DEP microfluidic chip can successfully separate CTCs from WBCs, RBCs, and platelets while reducing the required separation voltage to 4.5 volts. Due to the low voltage, Joule heating does not impact cell viability. This novel approach holds great promise for early cancer diagnosis and personalized medicine, providing a powerful tool for the non-invasive capture and analysis of rare tumor cells in clinical settings.